GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9473555 | 1 | rs3806988 | chr6:49431569 | MUT | chr6:49398994-49431031:- | 0.37 | 6.28 | 3.45E-9 | Folate pathway vitamin levels |
| UCEC | cis | rs9309473 | 1 | rs3813227 | chr2:73651967 | ALMS1P | chr2:73872046-73912692:+ | -0.52 | -6.13 | 7.12E-9 | Metabolite levels |
| UCEC | cis | rs9473555 | 1 | rs3823114 | chr6:49431720 | MUT | chr6:49398994-49431031:- | 0.35 | 5.81 | 3.59E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | TSFM | chr12:58176536-58191367:+ | -0.46 | -5.07 | 1.14E-6 | Multiple sclerosis |
| UCEC | cis | rs60843830 | 1 | rs3828165 | chr2:220889 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.41 | 1.7E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs12590640 | 1 | rs3844014 | chr14:36868831 | MBIP | chr14:36767764-36789882:- | 0.36 | 4.53 | 1.17E-5 | Malaria |
| UCEC | cis | rs10935120 | 1 | rs3846055 | chr3:134203973 | ANAPC13 | chr3:134196547-134204865:- | 0.42 | 4.75 | 4.73E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs3846056 | chr3:134227292 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs12590640 | 1 | rs3850275 | chr14:36860994 | MBIP | chr14:36767764-36789882:- | 0.37 | 4.74 | 4.9E-6 | Malaria |
| UCEC | cis | rs12590640 | 1 | rs3890569 | chr14:36866380 | MBIP | chr14:36767764-36789882:- | 0.38 | 4.91 | 2.28E-6 | Malaria |
| UCEC | cis | rs9815354 | 1 | rs3890604 | chr3:41760625 | ULK4 | chr3:41288091-42003660:- | 0.51 | 6.28 | 3.36E-9 | Diastolic blood pressure |
| UCEC | cis | rs12590640 | 1 | rs3906463 | chr14:36850842 | MBIP | chr14:36767764-36789882:- | 0.36 | 4.54 | 1.15E-5 | Malaria |
| UCEC | cis | rs12590640 | 1 | rs3906465 | chr14:36855888 | MBIP | chr14:36767764-36789882:- | 0.37 | 4.75 | 4.58E-6 | Malaria |
| UCEC | cis | rs12590640 | 1 | rs3916179 | chr14:36863093 | MBIP | chr14:36767764-36789882:- | 0.37 | 4.74 | 4.9E-6 | Malaria |
| UCEC | cis | rs10935120 | 1 | rs3932818 | chr3:134206069 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.46 | 1.57E-5 | Height |